Searchable abstracts of presentations at key conferences in endocrinology

ea0094p154 | Nursing Practice | SFEBES2023

Improving collaboration between endocrine patient support groups and the society for endocrinology

Breen Louise , Smith Vick , Okoro Grace , Turner Helen

Background: Patient Support Groups (PSG) play a key role in the support, education, research and training for patients and clinicians alike, as well as providing invaluable input to key documents e.g. Defining the Future of Endocrinology (DfE), highlighting the importance of a closer working relationship with SfE.About the PSG Network: Established in Sept 2021, the network includes representation from SfE affiliated PSG ...

ea0094p112 | Reproductive Endocrinology | SFEBES2023

Are we over scanning women with turner syndrome who have the lowest risk of aortic dissection?

Glatzel Hannah , Njue Faith , Turner Helen , Orchard Elizabeth

Women with Turner Syndrome (TS) are at significantly increased risk of aortic dilation and dissection. However, predicting the risk of aortic dissection (AoD) is difficult with many women attending annual appointments with time, travel and parking costs and resource implications. We developed a risk-based pathway based on the international guidelines, enabling closer follow up for those with a greater risk and reduce the frequency of appointments for those at the least risk.</...

ea0094p265 | Reproductive Endocrinology | SFEBES2023

Non-invasive assessment of liver abnormalities in turner syndrome: A Follow-up Study

Calanchini Matilde , Shipley Alexandra , Cobbold Jeremy , Tomlinson Jeremy , Turner Helen

Background: We have previously reported abnormal liver function tests (LFTs), FIB-4 scores and liver stiffness measurements (LSM, Fibroscan) in patients with Turner syndrome (TS), but longitudinal data defining the impact of TS on liver phenotype are limited.Methods: We undertook a retrospective longitudinal follow-up audit (OUH; 8348) of 24 women with TS who had abnormal LFTs and underwent at least 2 assessments (median...

ea0094p279 | Thyroid | SFEBES2023

Concurrent Myasthenia gravis (MG) and Graves’ ophthalmopathy (GO)

Naughton Aoife , Oustabassidis Eva , David Joel , Norris Jonathan , Turner Helen

Myasthenia gravis (MG) and GravesÂ’ ophthalmopathy (GO) share many clinical characteristics but may also co-exist. Both are autoimmune disorders mediated by organ specific pathogenic autoantibodies to membrane surface receptors. Differential diagnosis and/or co-existence provides a potential management challenge, and there is a paucity of demographic information regarding precise prevalence rates and concurrence of disease.Method: Re...

ea0094p282 | Thyroid | SFEBES2023

Thyroid eye disease in pregnant women with Graves disease: Experience from a specialized thyroid eye clinic

Dissanayake Harsha , Oustabassidis Eva , Norris Jonathan , Turner Helen

Background: Thyroid eye disease (TED) affects 25% of patients with GravesÂ’ disease (GD). GD affects nearly 1% of pregnancies. However, data on TED incidence, course, management and outcome in pregnancy are limited.Aims: To describe the prevalence, course and outcomes of TED in pregnant females.Methods: A retrospective analysis of electronic health records was conducted in a sp...

ea0077oc5.3 | Bone and Calcium | SFEBES2021

Role of Intact and C-Terminal FGF-23 Assays in the Investigation of Metabolic Bone Disease.

Jethwa Kishan , Bhatti Sumbal , Chipchase Allison , Piec Isabelle , Fraser William , Turner Jeremy

Fibroblast growth factor 23 (FGF-23) is a phosphatonin produced by osteocytes in response to serum phosphate concentration. Immunoassays are widely employed to detect C-terminal fragments of FGF-23 (cFGF-23). Quantitative assays for intact FGF-23 (iFGF-23) measurement are also available. Causes of increased FGF-23 include Tumour Induced Osteomalacia (TIO), X-linked hypophosphataemic rickets (XLH) and end stage renal disease (ESRD). We observed that some individuals, with no id...

ea0077op5.2 | Bone and Calcium | SFEBES2021

Society for Endocrinology / Parathyroid UK National Hypoparathyroidism Management Audit

Shen Kiam Jian , Sharma Vivek , Glenister Liz , Fraser William , Turner Jeremy

Individuals with chronic hypoparathyroidism sometimes receive suboptimal care with high frequency of unplanned hospitalisation and iatrogenic harm. In 2015 the European Society for Endocrinology published evidence base consensus guidelines on the management of chronic hypoparathyroidism. Using these consensus recommendations as audit standards we worked with the Society for Endocrinology and Parathyroid UK to conduct a national audit of management of chronic hypoparathyroidism...

ea0077p184 | Metabolism, Obesity and Diabetes | SFEBES2021

Does human serum impact differentiation and mitochondrial function of human LHCN-M2 skeletal muscle cells?

Turner Mark , Saini Amarjit , Brown Holly , Anisi Sara , Stewart Claire , Renshaw Derek

Introduction: Skeletal muscle cells enable investigation of myogenesis and metabolic function in vitro. Exposure to human serum can provide insight into the impact of endocrine factors upon differentiation and mitochondrial function of skeletal muscle. The aim of these experiments was to optimise the culture conditions using human serum, which it was hypothesised would enhance myogenesis and mitochondrial function of LHCN-M2 human skeletal muscle cells.<p class="a...

ea0077p112 | Reproductive Endocrinology | SFEBES2021

What is the prevalence and pattern of cancers in Turner syndrome? A single centre cohort study

Goindoo Ryan J , Dilrukshi M D S A , Bragg Fiona , Calanchini Matilde , Turner Helen

Background: Previous population studies suggest cancer morbidity is different in Turner syndrome (TS) compared to the background female population. Whilst gonadoblastoma is well recognized in TS with Y chromosome material, studies have suggested increased prevalence of skin tumours and meningioma but reduced incidence of breast cancer.Methods: Retrospective analysis of an adult TS clinic patient database identified women who developed cancer. Tumour type...

ea0081ep874 | Reproductive and Developmental Endocrinology | ECE2022

Have we ignored red cell parameters in Turner Syndrome? Results from a single specialist centre

Beck Katharina , Dilrukshi M d s a , Calanchini Matilde , Roy Noemi B A , Turner Helen E

Introduction: Anaemia and other haematological disorders have been reported in Turner Syndrome (TS). TS-related comorbidities (premature ovarian insufficiency, autoimmune hypothyroidism, coeliac disease and liver diseases) and treatments (hormone replacement [HRT] and growth hormone) are possible explanations. We aim to investigate the prevalence of abnormal full blood count (FBC) in adult TS and assess associated clinical characteristics.Methods: FBC pa...